Entrectinib Breaks Through With Japanese Approval for NTRK-Positive Tumors

June 18, 2019 – Entrectinib received its first regulatory approval, as Japan’s Ministry of Health, Labour and Welfare (MHLW) has approved the drug for the treatment of adult and pediatric patients with NTRK fusion–positive, advanced recurrent solid tumors. The MHLW based its decision on data from the phase II STARTRK-2, phase I STARTRK-1, and phase I ALKA-372-001 trials, as well as findings from the phase I/II STARTRK-NG pediatric study. In STARTRK-2, specifically … (leggi tutto)