 | | Anno I – Numero 8 | Comitato scientifico editoriale: Giuseppe Curigliano, Alessandra Fabi, Matteo Lambertini Editore: Intermedia, Direttore Responsabile: Mauro Boldrini | | | | Pubblicazioni recenti | Axillary Surgery in Breast Cancer – Primary Results of the INSEMA Trial
Background: Whether surgical axillary staging as part of breast-conserving therapy can be omitted without compromising survival has remained unclear. Methods: In this prospective, randomized, noninferiority trial, we investigated the omission of axillary surgery as compared with sentinel-lymph-node biopsy in patients with clinically node-negative invasive breast cancer staged as T1 or T2 (tumor size, ≤5 cm) who were scheduled to undergo breast-conserving surgery … Continua a leggere
| Imlunestrant with or without Abemaciclib in Advanced Breast Cancer
Background: Imlunestrant is a next-generation, brain-penetrant, oral selective estrogen-receptor (ER) degrader that delivers continuous ER inhibition, even in cancers with mutations in the gene encoding ERα (ESR1). Methods: In a phase 3, open-label trial, we enrolled patients with ER-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer that recurred or progressed during or after aromatase inhibitor therapy … Continua a leggere
| Metastasis-directed stereotactic radiotherapy and systemic treatment continuation for patients with oligoprogressive metastatic breast cancer
Background: About 15-20 % of patients with metastatic breast cancer (mBC) can experience oligoprogressive disease (OPD) in ≤ 5 sites of disease. Patients with OPD may benefit from metastasis-directed stereotactic radiotherapy (SBRT) to all sites of cancer progression while maintaining the same systemic treatment, aiming to prolong the time to next systemic treatment (NEST). This study aims to assess the outcomes provided by this multimodal … Continua a leggere
| Single-modality endocrine therapy versus radiotherapy after breast-conserving surgery in women aged 70 years and older with luminal A-like early breast cancer (EUROPA): a preplanned interim analysis of a phase 3, non-inferiority, randomised trial
Optimal therapy following breast-conserving surgery in older adults with low-risk, early-stage breast cancer remains uncertain. The EUROPA trial aims to compare the effects of radiotherapy and endocrine therapy as single-modality treatments on health-related quality of life (HRQOL) and ipsilateral breast tumour recurrence (IBTR) outcomes in this population … Continua a leggere
| Prognosis prediction with the IHC3 score in patients with node-negative, hormone receptor-positive, HER2-negative early breast cancer
Background: Prognostication has been used to identify patient populations that could potentially benefit from treatment de-escalation. In patients with hormone receptor-positive (HRpos), human epidermal growth factor receptor 2-negative (HER2neg) early breast cancer (eBC), treatment de-escalation classically involved omitting chemotherapy. With recently developed specialized therapies that require hands-on side-effect management … Continua a leggere
| | Videopillola | Le linee guida AIOM sul trattamento del mTNBC | Fabio Puglisi

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Breast Cancer: Challenges and Advances in Supportive Care I mercoledì dell’oncologia Webinar NON ECM, 8 gennaio 2025 dalle 17.00 alle 18.15
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Real world data and shared decision making: Navigating the intersection of quality, cost and survival FAD, 13 gennaio 2025
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BREAKING NEWS IN BREAST CANCER Convegno regionale AIOM Lazio Roma, 27 gennaio 2025
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XXII Conferenza Nazionale AIOM STUDI DI FASE I Torino, 28 febbraio – 1° marzo 2025
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