Targeting Renal Cell Carcinoma with a HIF-2 antagonist
Clear cell Renal Cell Carcinoma (ccRCC) is characterized by VHL inactivation. Because no other gene is mutated as frequently, and VHL mutations are truncal, VHL inactivation is regarded as the governing event. VHL loss activates HIF-2, and constitutive HIF-2 restores tumorigenesis ...Leggi tutto